Saturday, December 28, 2019

The Cultural Analysis of Memento - 1208 Words

Memento is an odd but successful film, and it is also an outstanding and influential cultural work. As an unusual crime film, it uses unconventional non-linear narrative structure to tell a story that a man with a unique type of amnesia investigate his wife’s murder. However, if we watch carefully, we would find Memento involves the real social cultural background. Memento was released in 2000 when was the beginning to enter the 21st century. It was the time that technology was developing into another stage. There were many technological products in the markets. These products have changed our living ways, and in particular, they have made us record the memory in more various ways. The protagonist of the movie, Leonard Shelby, has a special condition which causes him to suffer from short term memory loss and not to be able to make new memory. He seeks to revenge the murder of his wife, so he uses extensive Polaroid photos, tattoos, and notes to help himself keep track of thing s. Otherwise, he would not have any idea about what or how to do, where to go and so on. The development of technology has let photographs and tattoos to become widespread. The Polaroid photos are created by a Polaroid instant camera which is a popular camera product. Today there are diverse camera products with different functions. Taking photographs has become a very common way to mark the memory. Tattoo is a type of folk artistic culture. People usually have special individual purposes to makeShow MoreRelatedUnderstanding Image and Visual Media Artifact Essay884 Words   |  4 PagesCritically analyzing of visual media artifact investigates visual culture. An analysis entails image interpretation of image equally applicable to genres of photographs as form of advertisement. In this paper, I will critically examine photographs. According to Barrett (2011) he suggested that critic starts with description that involves developing a list of facts concerning the subject matter within the image. Description is a data gathering process of photograph (p. 17). It’s als o establishingRead MoreInternet Archiving Preserves The Live Web Essay979 Words   |  4 Pageshttps://www.raddadi.com and Star28 https://www.star28.com. Then, we defined the boundaries of determining if the URI is characterized as a website written in Arabic language. We found that 7976 URIs satisfied this criteria. After that, we performed some analysis on those Arabic URIs. In our work we found four main findings. First, we found that 41% of Arabic websites are not archived and that 31% of Arabic websites are not indexed by Google. Second, we found that only 6.6% of the Arabic URIs had Arabic countryRead MoreLets Stay Abreast Program Paper1589 Words   |  7 Pages18.8% has a Bachelor degree or higher (U.S. Census Bureau, 2015). Since the population is predominantly African American, there may be some resistance to seeking medical care, due to mistrust of the healthcare professions and ritual practices and cultural beliefs. Also, due to the age of the population following-up with medical appointments or receiving annual/biannual mammogram screening may be difficult for this group of people. There may exist the inability for them to get around because of physicalRead MoreThe Care Of A Good Death Essay2064 Words   |  9 PagesIntroduction The purpose of this paper is to analysis the care of a patient who endured the death of her baby while in nursing care. In doing so, the components of the Framework for a Good Death (Emanuel Emanuel, 1998) will be discussed. The goal is to examine the factors that come into play when caring for a patient who is experiencing grief and loss, as well as examine the multidisciplinary health disciplines utilized to offer the best of care when dealing with end-of-life decisions. WhatRead MoreDjango Unchained Analysis Essay2230 Words   |  9 Pages Dr. Schultz is a very intelligent and ingenious person who knows how to use his qualities to maneuver through life. Or is it muscle and strength as depicted in Mandingo fighting? As Deborah Khoshaba comments in her essay â€Å"Django Unchained: Film analysis, downloaded May 13. Regardless of what the traits that makes us most fit to survive, Tarantino uses them very clearly in this film for us to consider our own human nature. Thus, to a certain extent, we all can relate to some of Tarantino’s charactersRead More The Relationship of Photographs, History, and Memory Essay5378 Words   |  22 Pagescontrast to earlier times--has been chronicled by a visual narrative that relies on the attraction of photographs as means of storing and disseminating information. Photographs emerge as documents of a lived experience, and their presence in the cultural milieu of technologically enhanced contemporary communica tion practices remains virtually unchallenged at the threshold to the twenty-first century. Photographs are the story-telling companions of time, they direct the gaze of the spectator toRead More Constructing Fantasy in Hitchcocks Vertigo Essay3254 Words   |  14 PagesConstructing Fantasy in Hitchcocks Vertigo The amount of critical analysis surrounding Alfred Hitchcocks Vertigo is itself dizzying, but as the film has recently been restored, it seems appropriate to provide it with a fresh critical reading. The purpose of this paper then, is to draw this film out of the past with a reading that offers not only a new way of understanding it, but a close look at the culture that produced it. Specifically, Vertigo offers its most exciting ideas when contextualizedRead MoreMarketing Plan for Islands Souvenirs6289 Words   |  26 Pages 4 * INDUSTRY GROWTH/DECLINE PATTERNS 4-6 * PRODUCTS AND SERVICES 6-7 * CUSTOMER/CONSUMER BEHAVIOR 8 I-B. COMPETITOR ANALYSIS 9-11 I-C. INDUSTRY ANALYSIS * PEST ANALYSIS 12 * PORTER’S FIVE FORCES ANALYSIS 13 II. COMPANY PROFILE II-A. COMPANY BACKGROUND 14 II-B. COMPANY ANALYSIS * SWOT ANALYSIS 15-17 * GROWTH SALES 18 II-C. COMPANY’S MISSION/VISSION; GOALS amp; OBJECTIVES 19 II-D. MARKETING STRATEGIES AND PROGRAMSRead MoreCauses Effects of Broken Relationship3780 Words   |  16 Pagesencompasses a wealth of different feelings, from the passionate desire and intimacy of romantic love to the nonsexual emotional closeness of familial. Thus relationship in its various forms acts as a major facilitator. For further proceeding to this analysis of impact of broken relationship we now need to clarify how different types of relations are built and what are the facts that lead those relations to an unfair end meaning â€Å"break-up†. Interpersonal relationship: is a relatively long-term associationRead MoreEssay about C228 Task 1 WGU4749 Words   |  19 Pagesbeing violent crimes and fifty-six being property crimes (Neighborhood Scout, 2015). There are 136 crimes per square mile in [city/county name]. The national average is thirty-eight crimes per square mile (Neighborhood Scout, 2015). B3. Cultural Assessment The Cultural Assessment Tool was used to evaluate the practices and beliefs of the community. By using this tool, assessment was focused on religious affiliation, household composition, and political affiliation. Fifty-seven percent of the population

Friday, December 20, 2019

Causes and Effects of Global Warming Essay - 2371 Words

As Robert Frost once said, â€Å" Some say the world will end in fire, some say in ice. From what I’ve tasted of desire I hold with those who favor fire.† This excerpt can relate to the idea of global warming. Global warming can be defined as an increase in the earths average atmospheric temperature that causes corresponding changes in climate and that may result from the greenhouse effect. During the past 10,000 years the earth has been in an ever-growing cycle that has significantly changed the climate. These changes are becoming more prevalent in our world today in the past 150 years. Scientists have been analyzing the causes and effects of the greenhouse effect and many other issues that global warming has presented. As John Houghton†¦show more content†¦Aerosols have two major effects on the climate. They include direct and indirect radiation. â€Å" The cooling or warming of the atmosphere due to the reflective or absorbent properties of the particles ar e considered direct effects. Reflective particles cool the atmosphere by scattering energy from the sun back into space. Absorbent particles have the opposite effect. They add to atmospheric heating by absorbing the sun’s energy.† (Calipso Outreach) An indirect effect of aerosols is their roles on cloud condensation nuclei, CCN. The use of aerosols has a huge relationship with the amount of CCN present in a cloud. Clouds with more CCN, from the higher use of aerosols, are larger and more reflective than those with fewer CCN (Calipso Outreach). Since the clouds are more reflective, light is being trapped in the earth’s atmosphere. Ultimately creating the earths temperature to rise. In Calipso Outreach they explain, â€Å" The particles pushed into the atmosphere from a dust storm are made of minerals with both reflective and absorbent properties. The ability of the particles to absorb sunlight is thought to have a net warming effect on area of the atmosphere th ey occupy.† The particles from the dust storm get trapped up in the earth’s atmosphere, creating almost a mirror for sunlight to be reflected by. With the more sunlight being reflected, the hotter the temperature will be on Earth. Aerosols are a huge cause of globalShow MoreRelatedGlobal Warming : Causes And Effects905 Words   |  4 Pagesindependent variables that are contributing to the cause of a problem the world is currently faced with, global warming. What is global warming? Well, global warming is a rise in the Earth s average atmospheric temperature that causes corresponding changes in climate and that may result from the greenhouse effect (which I will talk more about.) Which is when our ozone layer has a hole which gradually increases, and increases heat from the sun. This causes major problems such as the polar caps meltingRead MoreCause And Effect Of Global Warming953 Words   |  4 Pagesunderstand the cause and effect of global warming, but it can take years for scientists to reach a consensus. The claims that global warming is the next apocalypse or is just some fairy tale lack scientific proof. These claims have confused the general public, and leave many citizens’ questions unanswered. Many people are concerned about the overall decline of environmental health due to an increase in man-made greenhouse gas emissions, but experts are now clarifying the debate on global warming with hardRead MoreGlobal Warming : Causes And Effects1369 Words   |  6 PagesGlobal Warming: Clearing up the Confusion to Become Part of the Solution Global warming, often confused with the term â€Å"climate change,† is a problem of worldly proportions that knows no limits, caused in large part by human actions. If it continues unchecked, its effects will be felt around the planet, from human society, to the environment, to the world economy. The purpose of this research paper is to understand the topic of global warming, its causes and effects, in order to help understandRead MoreGlobal Warming : Causes And Effects1325 Words   |  6 Pages Global warming is already taking place. It stopped being a prediction. The temperature at the earth’s surface has averagely increased by around 0.60 C.Both the oceans and the air are warming. It is believed that the greenhouses gases’ concentrations in the atmosphere have increased dramatically since the periods of pre-industrialization. This condition is caused by the activities of human beings most especially through the burning of fossil fuels such as natural gas, oil,Read MoreGlobal Warming : Causes And Effects973 Words   |  4 PagesGlobal warming has become a massive problem throughout the world, and as the population grows so do the effects of climate change. What people do not know is that it is the leading cause of the earth’s end and might be a minor cause of death in the far future. Global warming is one of the many things that humans have caused that has no easy fix. Professors Charles Kennel, V. Ramanathan, and David G. Victor at the University of California – San Diego say that â€Å"Greenhouse gas concentrations are trendingRead MoreGlobal Warming : Causes And Effects1206 Words   |  5 PagesGlobal warming is a naturally occurring phenomenon within our planet that needs to be reduced because it is affecting us in many harmful ways. It is one of the most current and widely discussed factors. It has been impacting us negatively in ways such as biodiversity and climate conditions. Several curr ent trends clearly demonstrate that global warming is directly impacting on rising sea levels, the melting of ice caps and significant worldwide climate changes. Over the years, scientists have conductedRead MoreGlobal Warming : Causes And Effects880 Words   |  4 PagesGlobal warming has increased significantly since the 1800s and is becoming a significant impact in our everyday lives. It is considered one of the most challenging environmental problems that exists today. Due to global warming, temperatures on Earth are rising and it’s affecting the way people live. Many people feel concerned about this issue while others could not care less. Developing countries do not understand the impact global warming has and how they should contribute to it while developedRead MoreGlobal Warming : Causes And Effects1453 Words   |  6 PagesGlobal Warming Introduction A slight change in temperature may not seem that bad but a small rise in global temperature can do a lot of damage. Global warming is an increase in the earth s average atmospheric temperature that causes corresponding changes in climate [11]. This report is going to discuss the many causes of global warming as well as the effects that come with it. It will also discuss ways to prevent global warming from happening. Causes of Global Warming Global warming is whatRead MoreGlobal Warming : Cause And Effect1471 Words   |  6 Pages Global warming (Cause/Effect) Jimareo Kimmons Comp I Dr. Sarthou 10/30/2015 Droughts, lengthy hot spells, heavy downpours, floods, and other extreme weather events are occurring more frequently and intensely every year. Around the world, research teams are analyzing these trends, noting the changes in temperature, rainfall, ice mass, sea level, and many other variables recorded by weather measuring devices. The trends are undeniable: the Earth is getting warmer. Polar sea iceRead MoreGlobal Warming : Causes And Effects1381 Words   |  6 PagesEarth is broken, and we all had a hand in breaking it, inadvertently though it may have been, by adding an abundance of greenhouse gases to the atmosphere that contribute directly to global warming; and we continue to do so every time we start our car, turn up the heat, turn on the lights or throw away trash. Global warming is a problem, caused in large part by human activity, and as it stands, poses a monumental threat to the planet and all of its occupants; while mega polluters do not have an incentive

Thursday, December 12, 2019

calvin Essay Example For Students

calvin Essay This man, undoubtedly the greatest of ../cathen/12495a.htm divines, and perhaps, after ../cathen/02084a.htm, the most perseveringly followed by his disciples of any Western writer on theology, was born at Noyon in Picardy, France, 10 July, 1509, and died at Geneva, 27 May, 1564. A generation divided him from ../cathen/09438b.htm, whom he never met. By birth, education, and temper these two protagonists of the reforming movement were strongly contrasted. Luther was a Saxon peasant, his father a miner; Calvin sprang from the French middle-class, and his father, an attorney, had purchased the freedom of the City of Noyon, where he practised civil and canon law. Luther entered the Order of Augustinian Hermits, took a monks vows, was made a priest and incurred much odium by marrying a nun. Calvin never was ordained in the Catholic Church; his training was chiefly in law and the humanities; he took no vows. Luthers eloquence made him popular by its force, humour, rudeness, and vulgar style . Calvin spoke to the learned at all times, even when preaching before multitudes. His manner is classical; he reasons on system; he has little humour; instead of striking with a cudgel he uses the weapons of a deadly logic and persuades by a teachers authority, not by a demagogues calling of names. He writes French as well as Luther writes German, and like him has been reckoned a pioneer in the modern development of his native tongue. Lastly, if we term the doctor of Wittenberg a mystic, we may sum up Calvin as a scholastic; he gives articulate expression to the principles which Luther had stormily thrown out upon the world in his vehement pamphleteering; and the Institutes as they were left by their author have remained ever since the standard of orthodox ../cathen/12495a.htm belief in all the Churches known as ../cathen/12710a.htm His French disciples called their sect the religion; such it has proved to be outside the Roman world. The family name, spelt in many ways, was Cauvin latinized according to the custom of the age as Calvinus. For some unknown reason the Reformer is commonly called Matre Jean C. His mother, Jeanne Le Franc, born in the ../cathen/03209c.htm, is mentioned as beautiful and devout; she took her little son to various shrines and brought him up a good Catholic. On the fathers side, his ancestors were seafaring men. His grandfather settled at Pont lEvque near Paris, and had two sons who became locksmiths; the third was Gerard, who turned procurator at Noyon, and there his four sons and two daughters saw the light. He lived in the Place au Bl (Cornmarket). Noyon, a bishops see, had long been a fief of the powerful old family of Hangest, who treated it as their personal property. But an everlasting quarrel, in which the city took part, went on between the bishop and the chapter. Charles de Hangest, nephew of the too well-known Georges dAmboise, Archbishop of Rouen, surrendered the bishopric in 1525 to his own nephew John, becoming his vicar -general. John kept up the battle with his canons until the Parliament of Paris intervened, upon which he went to Rome, and at last died in Paris in 1577. This prelate had ../cathen/12495a.htm kinsfolk; he is charged with having fostered heresy which in those years was beginning to raise its head among the French. Clerical dissensions, at all events, allowed the new doctrines a promising field; and the Calvins were more or less infected by them before 1530. Gerards four sons were made clerics and held benefices at a tender age. The Reformer was given one when a boy of twelve, he became Cur of Saint-Martin de Marteville in the Vermandois in 1527, and of Pont lEveque in 1529. Three of the boys attended the local Collge des Capettes, and there John proved himself an apt scholar. But his people were intimate with greater folk, the de Montmor, a branch of the line of Hangest, which led to his accompanying some of their children to Paris in 1523, when his mother was probably dead and his father had married again. The latter died in 1531, under excommunication from the chapter for not sending in his accounts. The old mans illness, not his lack of honesty, was, we are told, the cause. Yet his son Charles, nettled by the censure, drew towards the ../cathen/12495a.htm doctrines. He was accused in 1534 of denying the Catholic dogma of the ../cathen/05572c.htm, and died out of the Church in 1536; his body was publicly gibbeted as that of a recusant. Meanwhile, young John was going through his own trials at the University of Paris, the dean or syndic of which, Noel Bdier, had stood up against ../cathen/05510b.htm and bore hard upon ../cathen/09114b.htm (Stapulensis), celebrated for his translation of the Bible into French. Calvin, a martinet, or oppidan, in the College de la Marche, made this mans acquaintance (he was from Picardy) and may have glanced into his Latin commentary on St. Paul, dated 1512, which Doumergue considers the first ../cathen/12495a.htm book emanating from a French pen. Another influence tending the same way was that of Corderius, Calvins tutor, to whom he dedicated afterwards his annotation of I Thessalonians, remarking, if there be any good thing in what I have published, I owe it to you. Corderius had an excellent Latin style, his life was austere, and his Colloquies earned him enduring fame. But he fell under suspicion of heresy, and by Calvins aid took refuge in Geneva, where he died September 1564. A third herald of the New Learning was George Cop, physician to Francis I, in whose house Calvin found a welcome and gave ear to the religious discussions which Cop favoured. And a fourth was Pierre-Robert dOlivet of Noyon, who also translated the Scriptures, our youthful man of letters, his nephew, writing (in 1535) a Latin preface to the Old Testament and a French one his first appearance as a native author to the New Testament. By 1527, when no more than eighteen, Calvins educatlon was complete in its main lines. He had lea rned to be a humanist and a reformer. The sudden conversion to a spiritual life in 1529, of which he speaks, must not be taken quite literally. He had never been an ardent Catholic; but the stories told at one time of his ill-regulated conduct have no foundation; and by a very natural process he went over to the side on which his family were taking their stand. In 1528 he inscribed himself at Orlans as a law student, made friends with Francis Daniel, and then went for a year to Bourges, where he began preaching in private. Margaret dAngoulme, sister of Francis I, and Duchess of Berry, was living there with many heterodox Germans about her. He is found again at Paris in 1531. Wolmar had taught him Greek at Bourges; from Vatable he learned Hebrew; and he entertained some relations with the erudite Budaeus. About this date he printed a commentary on Senecas De Clementi. It was merely an exercise in scholarship, having no political significance. Francis I was, indeed, handling ../cathen /12495a.htm severely, and Calvin, now Doctor of Law at Orlans, composed, so the story runs, an oration on Christian philosophy which Nicholas Cop delivered on All Saints Day, 1532, both writer and speaker having to take instant flight from pursuit by the royal inquisitors. This legend has been rejected by modern critics. Calvin spent some time, however, with Canon du Tillet at Angoulme under a feigned designation. In May, 1534, he went to Noyon, gave up his benefice, and, it is said, was imprisoned. But he got away to Nerac in Bearn, the residence of the Duchess Margaret, and there again encountered Le Fvre, whose French Bible had been condemned by the Sorbonne to the flames. His next visit to Paris fell out during a violent campaign of the Lutherans against the ../cathen/10006a.htm, which brought on reprisals, Etienne de la Forge and others were burnt in the Place de Grve; and Calvin accompanied by du Tillet, escaped though not without adventures to Metz and Strasburg. In the lat ter city Bucer reigned supreme. The leading reformers dictated laws from the pulpit to their adherents, and this journey proved a decisive one for the French humanist, who, though by nature timid and shy, committed himself to a war on paper with his own sovereign. The famous letter to Francis I is dated 23 August, 1535. It served as a prologue to the Institutes, of which the first edition came out in March, 1536, not in French but in Latin. Calvins apology for lecturing the king was, that placards denouncing the ../cathen/12495a.htm as rebels had been posted up all over the realm. Francis I did not read these pages, but if he had done so he would have discovered in them a plea, not for toleration, which the Reformer utterly scorned, but for doing away with Catholicism in favour of the new gospel. There could be only one true Church, said the young theologian, therefore kings ought to make an utter end of popery. (For an account of the Institutes see ../cathen/03198a.htm) The second edition belongs to 1539, the first French translation to 1541; the final Latin, as revised by its author, is of 1559; but that in common use, dated 1560, has additions by his disciples. It was more Gods work than mine, said Calvin, who took for his motto Omnia ad Dei gloriam, and in allusion to the change he had undergone in 1529 assumed for his device a hand stretched out from a burning heart. A much disputed chapter in Calvins biography is the visit which he was long thought to have paid at Ferraro to the ../cathen/12495a.htm Duchess Rene, daughter of Louis XII. Many stories clustered about his journey, now given up by the best-informed writers. All we know for certain is that the Reformer, after settling his family affairs and bringing over two of his brothers and sisters to the views he had adopted undertook, in consequence of the war between ../cathen/03625a.htm and Francis I, to reach Bale by way of Geneva, in July, 1536. At Geneva the Swiss preacher Fare, then looking for hel p in his propaganda, besought him with such vehemence to stay and teach theology that, as Calvin himself relates, he was terrified into submission. We are not accustomed to fancy the austere prophet so easily frightened. But as a student and recluse new to public responsibilities, he may well have hesitated before plunging into the troubled waters of Geneva, then at their stormiest period. No portrait of him belonging to this time is extant. Later he is represented as of middle height, with bent shoulders, piercing eyes, and a large forehead; his hair was of an auburn tinge. Study and fasting occasioned the severe headaches from which he suffered continually. In private life he was cheerful but sensitive, not to say overbearing, his friends treated him with delicate consideration. His habits were simple; he cared nothing for wealth, and he never allowed himself a holiday. His correspondence, of which 4271 letters remain, turns chiefly on doctrinal subjects. Yet his strong, reserved character told on all with whom he came in contact; Geneva submitted to his theocratic rule, and the ../cathen/12710a.htm accepted his teaching as though it were infallible. Such was the stranger whom Farel recommended to his fellow ../cathen/12495a.htm, this Frenchman, chosen to lecture on the Bible in a city divided against itself. Geneva had about 15,000 inhabitants. Its bishop had long been its prince limited, however, by popular privileges. The vidomne, or mayor, was the Count of Savoy, and to his family the bishopric seemed a property which, from 1450, they bestowed on their younger children. John of Savoy, illegitimate son of the previous bishop, sold his rights to the duke, who was head of the clan, and died in 1519 at Pignerol. Jean de la Baume, last of its ecclesiastical princes, abandoned the city, which received ../cathen/12495a.htm teachers from Berne in 1519 and from Fribourg in 1526. In 1527 the arms of Savoy were torn down; in 1530 the Catholic party underwent defeat , and Geneva became independent. It had two councils, but the final verdict on public measures rested with the people. These appointed Farel, a convert of Le Fevre, as their preacher in 1534. A discussion between the two Churches from 30 May to 24 June, 1535 ended in victory for the ../cathen/12495a.htm. The altars were desecrated, the sacred images broken, the Mass done away with. Bernese troops entered and the Gospel was accepted, 21 May, 1536. This implied persecution of Catholics by the councils which acted both as Church and State. Priests were thrown into prison; citizens were fined for not attending sermons. At Zrich, Basle, and Berne the same laws were established. Toleration did not enter into the ideas of the time. But though Calvin had not introduced this legislation, it was mainly by his influence that in January, 1537 the articles were voted which insisted on communion four times a year, set spies on delinquents, established a moral censorship, and punished the unruly w ith excommunication. There was to be a childrens catechism, which he drew up; it ranks among his best writings. The city now broke into jurants and nonjurors for many would not swear to the articles; indeed, they never were completely accepted. Questions had arisen with Berne touching points that Calvin judged to be indifferent. He made a figure in the debates at Lausanne defending the freedom of Geneva. But disorders ensued at home, where recusancy was yet rife; in 1538 the council exiled Farel, Calvin, and the blind evangelist, Couraud. The Reformer went to Strasburg, became the guest of Capito and Bucer, and in 1539 was explaining the New Testament to French refugees at fifty two florins a year. Cardinal Sadolet had addressed an open letter to the Genevans, which their exile now answered. Sadolet urged that schism was a crime; Calvin replied that the Roman Church was corrupt. He gained applause by his keen debating powers at Hagenau, Worms, and Ratisbon. But he complains of his p overty and ill-health, which did not prevent him from marrying at this time Idelette de Bure, the widow of an Anabaptist whom he had converted. Nothing more is known of this lady, except that she brought him a son who died almost at birth in 1542, and that her own death took place in 1549. After some negotiation Ami Perrin, commissioner for Geneva, persuaded Calvin to return. He did so, not very willingly, on 13 September, 1541. His entry was modest enough. The church constitution now recognized pastors, doctors, elders, deacons but supreme power was given to the magistrate. Ministers had the spiritual weapon of Gods word; the consistory never, as such, wielded the secular arm Preachers, led by Calvin, and the councils, instigated by his opponents, came frequently into collision. Yet the ordinances of 1541 were maintained; the clergy, assisted by lay elders, governed despotically and in detail the actions of every citizen. A presbyterian Sparta might be seen at Geneva; it set an exa mple to later Puritans, who did all in their power to imitate its discipline. The pattern held up was that of the Old Testament, although Christians were supposed to enjoy Gospel liberty. In November, 1552, the Council declared that Calvins Institutes were a holy doctrine which no man might speak against. Thus the State issued dogmatic decrees, the force of which had been anticipated earlier, as when Jacques Gouet was imprisoned on charges of impiety in June, 1547, and after severe torture was beheaded in July. Some of the accusations brought against the unhappy young man were frivolous, others doubtful. What share, if any, Calvin took in this judgment is not easy to ascertain. The execution of however must be laid at his door; it has given greater offence by far than the banishment of Castellio or the penalties inflicted on Bolsec moderate men opposed to extreme views in discipline and doctrine, who fell under suspicion as reactionary. The Reformer did not shrink from his self-app ointed task. Within five years fifty-eight sentences of death and seventy-six of exile, besides numerous committals of the most eminent citizens to prison, took place in Geneva. The iron yoke could not be shaken off. In 1555, under Ami Perrin, a sort of revolt was attempted. No blood was shed, but Perrin lost the day, and Calvins theocracy triumphed. I am more deeply scandalized, wrote Gibbon at the single execution of Servetus than at the hecatombs which have blazed in the autos-da-f of Spain and Portugal. He ascribes the enmity of Calvin to personal malice and perhaps envy. The facts of the case are pretty well ascertained. Born in 1511, perhaps at Tudela, Michael Served y Reves studied at Toulouse and was present in Bologna at the coronation of ../cathen/03625a.htm. He travelled in Germany and brought out in 1531 at Hagenau his treatise De Trinitatis Erroribus, a strong Unitarian work which made much commotion among the more orthodox Reformers. He met Calvin and disputed with him at Paris in 1534, became corrector of the press at Lyons; gave attention to medicine, discovered the lesser circulation of the blood, and entered into a fatal correspondence with the dictator of Geneva touching a new volume Christianismi Restitutio, which he intended to publish. In 1546 the exchange of letters ceased. The Reformer called Servetus arrogant (he had dared to criticize the Institutes in marginal glosses), and uttered the significant menace, If he comes here and I have any authority, I will never let him leave the place alive. The Restitutio appeared in 1553. Calvin at once had its author delated to the Dominican inquisitor Ory at Lyons, sending on to him the mans letters of 1545-46 and these glosses. Hereupon the Spaniard was imprisoned at Vienne, but he escaped by friendly connivance, and was burnt there only in effigy. Some extraordinary fascination drew him to Geneva, from which he intended to pass the Alps. He arrived on 13 August, 1553. The next day Calvin, who ha d remarked him at the sermon, got his critic arrested, the preachers own secretary coming forward to accuse him. Calvin drew up forty articles of charge under three heads, concerning the ../cathen/06612a.htm, infant baptism, and the attack which Servetus had ventured on his own teaching. The council hesitated before taking a deadly decision, but the dictator, reinforced by Farel, drove them on. In prison the culprit suffered much and loudly complained. The Bernese and other Swiss voted for some indefinite penalty. But to Calvin his power in Geneva seemed lost, while the stigma of heresy; as he insisted, would cling to all ../cathen/12495a.htm if this innovator were not put to death. Let the world see Bullinger counselled him, that Geneva wills the glory of Christ. Accordingly, sentence was pronounced 26 October, 1553, of burning at the stake. Tomorrow he dies, wrote Calvin to Farel. When the deed was done, the Reformer alleged that he had been anxious to mitigate the punishment, but of this fact no record appears in the documents. He disputed with Servetus on the day of execution and saw the end. A defence and apology next year received the adhesion of the Genevan ministers. Melanchthon, who had taken deep umbrage at the blasphemies of the Spanish Unitarian, strongly approved in well-known words. But a group that included Castellio published at Basle in 1554 a pamphlet with the title, Should heretics be persecuted? It is considered the first plea for toleration in modern times. Beza replied by an argument for the affirmative, couched in violent terms; and Calvin, whose favorite disciple he was, translated it into French in 1559. The dialogue, Vaticanus, written against the Pope of Geneva by Castellio, did not get into print until 1612. Freedom of opinion, as Gibbon remarks, was the consequence rather than the design of the ../cathen/12700b.htm. Another victim to his fiery zeal was Gentile, one of an Italian sect in Geneva, which also numbered among its adheren ts Alciati and Gribaldo. As more or less Unitarian in their views, they were required to sign a confession drawn up by Calvin in 1558. Gentile subscribed it reluctantly, but in the upshot he was condemned and imprisoned as a perjurer. He escaped only to be twice incarcerated at Berne, where in 1566, he was beheaded. Calvins impassioned polemic against these Italians betrays fear of the ../cathen/14113a.htm which was to lay waste his vineyard. Politically he leaned on the French refugees, now abounding in the city, and more than equal in energy if not in numbers to the older native factions. Opposition died out. His continual preaching, represented by 2300 sermons extant in the manuscripts and a vast correspondence, gave to the Reformer an influence without example in his closing years. He wrote to Edward VI, helped in revising the ../cathen/02678c.htm, and intervened between the rival English parties abroad during the ../cathen/09766a.htm period. In the ../cathen/07527b.htm troubl es he sided with the more moderate. His censure of the conspiracy of Amboise in 1560 does him honour. One great literary institution founded by him, the College, afterwards the University, of Geneva, flourished exceedingly. The students were mostly French. When Beza was rector it had nearly 1500 students of various grades. Geneva now sent out pastors to the French congregations and was looked upon as the ../cathen/12495a.htm Rome. Through ../cathen/08680a.htm, the Scottish champion of the Swiss Reformation, who had been preacher to the exiles in that city, his native land accepted the discipline of the Presbytery and the doctrine of predestination as expounded in Calvins Institutes. The Puritans in England were also descendants of the French theologian. His dislike of theatres, dancing and the amenities of society was fully shared by them. The town on Lake Leman was described as without crime and destitute of amusements. Calvin declaimed against the Libertines, but there is no evide nce that any such people had a footing inside its walls The cold, hard, but upright disposition characteristic of the ../cathen/12710a.htm, less genial than that derived from Luther, is due entirely to their founder himself. Its essence is a concentrated pride, a love of disputation, a scorn of opponents. The only art that it tolerates is music, and that not instrumental. It will have no ../cathen/06021b.htm in its calendar, and it is austere to the verge of ../cathen/09591a.htm hatred of the body. When dogma fails the ../cathen/03198a.htm, he becomes, as in the instance of Carlyle, almost a pure Stoic. At Geneva, as for a time in Scotland, says J. A. Froude, moral sins were treated as crimes to be punished by the magistrate. The Bible was a code of law, administered by the clergy. Down to his dying day Calvin preached and taught. By no means an aged man, he was worn out in these frequent controversies. On 25 April, 1564, he made his will, leaving 225 French crowns, of which he bequ eathed ten to his college, ten to the poor, and the remainder to his nephews and nieces. His last letter was addressed to Farel. He was buried without pomp, in a spot which is not now ascertainable. In the year 1900 a monument of expiation was erected to Servetus in the Place Champel. Geneva has long since ceased to be the head of ../cathen/03198a.htm. It is a rallying point for ../cathen/06258b.htm, ../cathen/14062a.htm propaganda, and ../cathen/11074a.htm conspiracies. But in history it stands out as the Sparta of the ../cathen/12710a.htm, and Calvin is its Epidemiology in Nutrition Essay

Wednesday, December 4, 2019

”Hard Times” by Charles Dickens Essay Sample free essay sample

Josiah Bounderby falsely claims his success in life was a consequence of his difficult work and neer having aid from anyone in Charles Dickens’ Hard Times. Claiming to be a self-made adult male grants Mr. Bounderby broad esteem in Coketown. with the exclusion of Tom and Louisa Gradgrind and Mrs. Sparsit. who perceive him to be an impudent individual. Tom mirrors Mr. Bounderby’s selfish and hypocritical personality. but blames the old adult male for his stiff upbringing. Louisa can non look up to Mr. Bounderby while he unashamedly objectifies her when prosecuting her romantically. At the same clip. Mrs. Sparsit values Mr. Bounderby’s ability to assist her preserve her societal rank in Coketown instead than his accomplishments. These three characters see Mr. Bounderby though different points of position in comparing to the remainder of Coketown. influenced by the the function he plays in their lives. Similar to Mr. We will write a custom essay sample on †Hard Times† by Charles Dickens Essay Sample or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Bounderby. Tom claims to be a self-made adult male. However. Tom deems him to be unsophisticated. Upon Tom and Mr. Bounderby’s foremost encounter with Mr. Harthouse. Mr. Bounderby aggrandizes the â€Å"exact deepness of the trough [ he had ] lifted himself out of. better [ than ] any man† ( 120 ) . On the other manus. Tom first takes â€Å"an observation of his friend. † before enjoying about his ability to pull strings his manner to Mr. Bounderby’s side ( 127 ) . The bizarre behaviour Mr. Bounderby introduces himself has him look crackbrained in visible radiation of Tom’s composure and cautious attack. Tom’s careful appraisal of Mr. Harthouse alludes to his character’s dark attributes that manifest from his hate for Mr. Bounderby. Tom is profoundly disturbed as a consequence of his upbringing. for that ground he can non forgive Mr. Bounderby’s function in it. During a conversation with Louisa. Tom reveals his desire to â€Å"collect all the Facts†¦ and all the Figures. and all the people who found them. † so â€Å"put a thousand barrels of gunpowder under them. and blow them all together† ( 23 ) . The in writing phantasy Tom communicates to his sister depicting the annihilation of Thomas Gradgrind and Mr. Bounderby e xemplifies his dissatisfaction with himself and his bitterness towards them. Tom can non look up to Mr. Bounderby for his self-realized success because Tom blames him for his unrealized life. cognizing lone facts and nil on accomplishing felicity. Louisa portions Tom’s bitterness towards Mr. Bounderby and perceives him to be â€Å"a great trade rougher and non half so kind† ( 54 ) . Mr. Bounderby’s romantic chases aggravate Louisa. which consequence in her deficiency of regard. At the start of the novel. Louisa and Tom are caught by their male parent glancing into the circus and Mr. Bounderby guides their father’s choler towards the circus people alternatively of the kids. after which Mr. Bounderby harrasses Louisa for a buss as agencies of compensation. She raises her cheek â€Å"ungraciously† for him and one time he is gone she rubs the same cheek until â€Å"it was firing red† denoting to her brother that he could â€Å"cut the piece out with [ his ] penknife† and she â€Å"wouldn’t cry† ( 25 ) . More disturbed by his romantic chases than his engagement in her childhood. Mr. Bounderby abandons his function of guardian to one of an antagonizer in Louisa’s life. Mrs. Sparsit is obsessed with keeping a good societal ranking after her blue elect household fell to hard times and recognizes that Mr. Bounderby is the best manner to accomplish her end. Although Mrs. Sparsit needs Mr. Bounderby. she does non esteem him while taking â€Å"such commiseration on Mr. Bounderby to his face† so calls â€Å"his portrayal a Noodle to its face. with the greatest bitterness and contempt† after his bank had been robbed ( 188 ) . Mrs. Sparsit is a dissembler to Mr. Bounderby. whom she perceives as a simpleton. so that she may be able to remain in is good graces since she depends on him to maintain her respectable in the eyes of society. Furthermore. Mrs. Sparsit cares small about the alterations in Mr. Bounderby’s life. since they are non friends. as long they do non impact her societal ranking. After get marrieding Louisa. Mr. Bounderby offers Mrs. Sparsit an flat at the Bank to which her lone concern was non â€Å"‘descending lower in the societal scale’† ( 102 ) . Incarnating pure egoism. Mrs. Sparsit uses Mr. Bounderby as a tool which she manipulates to acquire what she desires. Coketown’s Utilitarian-like society allow Mr. Bounderby to ridiculously glee about his supposed self-made success ; however. Tom and Louisa Gradgrind. along with Mrs. Sparsit all take offense to Mr. Bounderby. The function Mr. Bounderby plays in each of the characters’ lives helps them admit his defect which prevent them from look up toing him. Tom’s bitterness. Louisa’s abhor of his romantic chases. and Mrs. Sparsit’s egoism all let them to stay unphased by Mr. Bounderby†™s repute. Work Cited Dickens. Charles. Hard Times. New York: Oxford UP. 2008. Print.

Thursday, November 28, 2019

A Merchandise Management Analysis of Spar Supermarkets free essay sample

Through this we assume that the main focus of merchandise management for a retailer is to attract consumers by catering for their needs and wants. These needs and wants can be determined through demographical segmentation of the area around the retailer, focusing on an area of two kilometers around the retailer. An underlying assumption for the project is then made which will be proved or disproved through the careful observation of two different retailers. The assumption The merchandise management of a retail store is directly influenced by the demographics of the area around the retail store, especially that area within two kilometers of the store. Two retailers in different of the same company will be used in order to emphasis that the differences found within the retail stores stem from the demographics of the immediate area around the store. Observation research will be used to observe the anagement of inventory within the two retailers so that bias is limited to the observer and not influenced by consumers that are shopping within the store. We will write a custom essay sample on A Merchandise Management Analysis of Spar Supermarkets or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page This however has a disadvantage in that the findings cannot be generalized to all retailers. The observations will be tallied in a table in order to easily determine the differences and through the interpretation of this information we will be able to determine the cause of the specific merchandise decisions and if it relates to the underlying assumption. From the interpretation and the theory that has been acquired, recommendations bout inventory management will be suggested in order to improve the amount of consumers that enter and shop at the retailer. Finally, a conclusion about whether the underlying assumption is supported by the evidence or in other words whether it is correct or not, will be made. 3 THEORETICAL DISCUSSION Managing merchandise In SUPERSPAR is a very particular exercise. There are many aspects of the merchandise and the store layout in order to maximize its efficiency as well as its sales with regard to the market that surrounds it. The grocery shopping experience is characterized by (1) multiple buying goals that must be achieved hrough the processing of a lot of in-store information such as products, brands, and point-of-purchase or POP information, and (2) repetition at regular time intervals (Whan Park, lyer Smith, 1989). This means that purchasing intentions and outcomes often differ because of a variety of factors relating to a customers situation or perhaps a group or segment of consumers situation. There are two factors influencing the purchasing of goods by consumers, these are time pressure and the knowledge of the store environment. These two factors are positively related to each other in that the consumers have a good knowledge of a etail store then they can usually reduce the time it takes to purchase what they need. Thus the ease of finding a product has some influence on the effects of failing to make an intended purchase (Whan Park, lyer Smith, 1989).ves.

Sunday, November 24, 2019

Doryphoros by Polykleitos essays

Doryphoros by Polykleitos essays Sculptors of the Early and High Classical Grecian periods in art strived for perfection in creating the human form. They combined such features such as regular facial features, smooth skin, and particular body portions into an ideal of perfect beauty. Much as modern day advertisement has idealized the slender model as the new perfect female form. One such artist of the time was named Polykleitos of Argos. He was a well-known sculptor and art theorist. His aim in sculpting was to produce the perfect human figure using a mathematical equation to sculpt the body parts. It is believed that he used a basic unit ratio to measure the rest of the body parts. He set down his theory on the human for in a treatise known as The Canon and created a larger than life size sculpture he named Doryphoros and is now called The Spear Bearer. Unfortunately nobody knows exactly what that unit of measurement was because neither his treatise nor his statue survived the centuries. The Spear Bearer was created out of bronze, a popular medium at the time because of the ability to show more movement in bronze than in marble, which was the traditional medium. The Spear Bearer was one of the earliest statues to be show in the fully developed contraposto position. Earlier Greek artisans came up with the idea of contraposto. This is where all the weight of the figure in question appears to put all its weight onto one leg. This technique makes Doryphoros appear to be relaxed but a certain tension is there and he is ready to spring into action at a moments notice. Polykleitos combined this with a system called chiastic balance or cross balance where there is an active-passive sense of balance. The right arm of The Spear Bearer is relaxed and languid at his side while the left has tension from holding the spear over his shoulder. His right leg the opposite of the right arm and tensed t ...

Thursday, November 21, 2019

Developmental psychology Essay Example | Topics and Well Written Essays - 500 words

Developmental psychology - Essay Example This viewpoint leaves no room for the nature part of the debate because if the mind is blank at birth, this means that there has been no role of genetics or heredity. According to him, it is only the nurture that shapes and stimulates the mind because at the time of our birth, we do not own any already developed personality traits. This points to the fact that a child can be made to develop any kind of personality through nurture which includes his social interactions, surroundings, experiences, cultural aspects, religion, and etcetera. Hence, according to Locke, a child’s mind depends upon the society for its formulation. Jean Jacques Rousseau’s views on nature versus nurture debate The French philosopher, Rousseau, believed that the nature is responsible for the development of behavioral characteristics of an individual and contrary to what Locke’s believed, Rousseau stated that human mind is somewhat developed when a child is born and it does show behavior tha t the child has inherited from its parents (Crain). That means genes are responsible for the makeup of the human mind. Rousseau believed that no one of us knows what our nature wants us to become. We are helpless because whatever our nature, inherited to us through biological factors, has intended for us will come our way.

Wednesday, November 20, 2019

Economics Essay Example | Topics and Well Written Essays - 1750 words - 1

Economics - Essay Example The main reason for the differences coming short may so be given by the treasury was the previous failings of monetary policy. In their description of the new monetary framework of October 1999, the principal argument was that previously there had been that numerous shortcomings in the design and conduct of monetary policy. Objectives were often inappropriate or unclear, while decisions were often poorly coordinated with fiscal policy or were made too late to prevent inflationary pressures from building. Roles and responsibilities were also ill-defined, creating the impression that policy decisions could be based on short-term political considerations. A lack of transparency hindered accountability and meant that policy-makers were unable to build credibility (Balls, & ODonnell, 2002). Given that the Treasury was conducting both monetary and fiscal policy prior to giving independence to the Bank, this is a remarkable statement. It seems to be either a vote of no confidence in the Treasury, or in the incoming government. It was argued that previous governments had often accompanied an apparently tough budget with an interest rate cut, only to raise interest rates again shortly afterwards, when the budget proved more inflationary than expected. As a result, they proposed that a test of fiscal policy was whether an independent Bank would change interest rates following a budget. Their finding under the new monetary policy arrangements was that interest rate changes did not seem related to the previous budget (Goodhart, 2006). A possible test of what type of policy the Bank is pursuing may be possible when the Bank is faced by a supply shock. Interest rates control inflation through their effect on aggregate demand. Since a positive aggregate demand shock raises demand and inflation, the correct monetary policy response would be to offset the increase in aggregate demand by higher interest rates. In contrast, a negative supply shock- say an oil price increase,

Sunday, November 17, 2019

U.S. Car Companies Essay Example | Topics and Well Written Essays - 2500 words

U.S. Car Companies - Essay Example The huge demand for the products of this industry in the domestic market of U.S., allowed the companies in the industry to enjoy economies of mass production (scale economies). This helped to speed up the rate of growth of the industry. At the beginning in 1890s, the U.S. auto industry began with approximately 100 automobile companies. These companies used to employ several modern technologies in their product and production processes. Steam engines, internal combustion engines and battery powered engines were the various types of engines found in the cars manufactured by these companies. Since that time, electric cars were available in the nation. The use of steam cars was also famous in the country; however, at times of cold weather, these cars could not be used. Lack of proper road infrastructure hindered this industry from expanding in the initial years. The Federal Aid Road in 1916 and the Federal Aid Highway Act in 1921, helped in allocation of substantial funds in U.S., to build proper roads. In 1896, Henry Ford introduced a new car company named The Ford Motor Company in U.S. Model T was the first model produced and sold by the company and its worth at that time was about $850. The model of the company became very famous in U.S. market and experienced high demand. High demand helped the company to enjoy economies of scale in production. This in turn reduced the cost of production and hence, profit and soon made the organization the largest auto company in the world. The next famous prominent auto company of U.S. that had become famous in the world market was General Motors Corporation (Hirsch 245). The company was founded by William Durant in 1908. The company acquired many small car producing firms, like, Cadillac and soon became a strong competitor of Ford Motor Company in the industry. Chrysler Group LLC was another famous car manufacturing company in

Friday, November 15, 2019

Lesch-Nyhan Syndrome: Physiology and Features

Lesch-Nyhan Syndrome: Physiology and Features Discuss the inheritance, molecular and biochemical defects underlying the clinical features associated with Lesch-Nyhan syndrome. The Lesch-Nyhan syndrome is a rare heritable disorder of inborn error metabolism of purine which was examined in 1964 by Lesch and Nyhan. They investigated the two brothers with hyperuricemia and neurobehavioral problems and suggested that this disorder involves motor impairment and self-injurious behaviors (Lesch, M and Nyhan, W. L., 1964). The popularity of Lesch-Nyhan syndrome is about 1 in 380000 individuals and this disorder presents solely in male. (Seegmiller, J. E., et al, 1967). It is passed on since the X-linked recessive trait causes genetic mutation followed by the exertion of an enzyme called hypoxanthine guanine phosphoribosyltransferase (HGPRT). In the metabolic condition, Lesch-Nyhan syndrome is recognized by purine overproduction (Nyhan, W. L, et al, 1967) which contributes to increased level of uric acid significantly. The clinical features associate with Lesch-Nyhan syndrome are briefly outlined and the inheritance, molecular and biochemical defects underlying the clinical features are also discussed. Figure 1. The clinical features associated with Lesch-Nyhan syndrome. This disorder leads to neurobehavioral syndrome involving motor dysfunction, cognitive impairment and self-injurious behaviors (Mumues, 2015).    The clinical characteristics of Lesch-Nyhan syndrome are defined by motor defection leading to neurological operation, cognitive and behavioral impairment, and also overproduction of uric acid or hyperuricemia (van der Zee et al., 1968). Moreover, neurological disturbance is majorly performed as hypotonia and developmental delay which are obviously expressed by three to six months. The children are interrupted in sitting and walking or require a wheelchair in severe condition. Additionally, the twitch of facial muscles and limbs can be observed in elder children. During the first ages, the extrapyramidal difficulties such as dystonia and choreoathetosis or the pyramidal difficulties like spasticity and hyperreflexia become noticeable (Jinnah and Friedmann, 2001). Furthermore, cognitive dysfunction and behavioral impairment occurring between two to three years old can lead to moderate or serious mental hindrance. Also, the continuous self-injurious behaviors such as biting the fingers or lips and hitting the head or limbs are the most distinctive behavioral symptom in patients (Nyhan, W. L, et al, 1968). Lesch-Nyhan syndrome is also characterized by overproduction of uric acid and this induces the decomposition of uric acid crystals in kidneys, ureters or bladder and the gouty arthritis can be developed later in the disorder (Page et al, 1987). Figure 2. The inheritance detects of Lesch- Nyhan syndrome. This X-linked recessive syndrome is solely for the male and the chance taken from the sons and daughters with either affected father and unaffected mother or unaffected father and carrier mother are showed (IFFA, 2016). Firstly, the Lesch- Nyhan syndrome is inherited in an X-linked recessive characteristic since the mutation of HPRT gene is positioned on the X chromosome and this disorder is described to the male only (Hoefnagel et al, 1965). More importantly, the X-linked inheritance determined that the X-linked character cannot be transferred from the father to the son. In this syndrome, the Lyon hypothesis can be adopted to demonstrate the mothers are heterozygous and the mosaics involve two cell cultures where one is entirely normal and another one is fully faulty (Migeon et al, 1968) . An investigation is examined that the fibroblasts developing in the cell populations from the skin were duplicated (Migeon, B. R, et al, 1968) and HGPRT deficiency in the negative duplication can be observed through radioautographical method. Furthermore, the halt of the X chromosome is not described as a random activity because HGPRT in the erythrocytes or leukocytes of obliged heterozygotes for this situation i s distinct with the glucose 6-phosphate dehydrogenase (G6PD) deficiency where the transportation of enzyme in heterozygotes is around 50%. It is indicated that the enzyme action in the erythrocytes of the mothers with Lesch-Nyhan syndrome are normal. Also, the blood-relative family in two kinds of G6PD and HGPRT (Nyhan, W. L.et al, 1970) are separating so this shows that females were heterozygous to G6PD. The reason why the males have more frequent chance to suffer from this X linked recessive syndrome than the females is because the males contain only one X chromosome and one changed copy of the gene is enough to lead to this syndrome and it is uncommon that females possess two changed copies of the gene Vogel (1977). It is examined that the father of a male patient is not the carrier of the mutated gene and also do not suffer from the syndrome. The chance taken from the siblings rely upon the carrier condition of the mother. Carrier women contain a 50% chance of passing on the HPRT1 variation in each gestation. The sons who receive that variation will be influenced and the daughters who obtain the variation are served as carriers. Hence, it can be concluded that a carrier mother has a one-fourth chance of getting an affected son, one-fourth chance of getting a carrier daughter and half chance of getting a normal son or daughter (Genetic Home Reference, 2007). Figure 3. Purine metabolism with de novo synthesis and salvage synthesis. The de novo purine synthesis is mobilized by the enzyme, PRPP amidotransferase, and the salvage pathway by hypoxanthine phosphorybosyltransferase (HPRT) and adenine phosphorybosyltransferase (APRT). HPRT catalyzes the salvage synthesis of inosine monophosphate, IMP, and guanosine monophosphate, GMP, from hypoxanthine and guanine particularly by using PRPP as a co-substrate. The HPRT deficiency leads to decomposition of hypoxanthine and guanine which are transformed into uric acid by xanthine oxidase. Purine overproduction, increase level of PRPP and decrease level of IMP and GMP are the results (Torres R J and Puig J G, 2007). Secondly, Lesch-Nyhan syndrome contributes to the molecular defects due to the mutation of HPRT1 gene which encrypts hypoxanthine phosphoribosyltransferase. This enzyme is used to recycle purines and is responsible for transferring hypoxanthine and guanine back into DNA synthesis which establish the cells to possess enough supply of building blocks and assemble DNA and RNA (Sweetman, L and Nyhan, W. L. 1972). The deficiency of HPRT map to chromosome Xq26-q27.2 and is likely to cause heterogenous mutations (Greene, M. L, et al, 1970). Also, it induces the increased level of purine nucleotides by purine salvage pathway. It leads to decomposition of uric acid because of the broken down but unrecycled purines and occurrence of excessive PRPP, resulting in the neurological and behavioral problems of Lesch-Nyhan syndrome (Kelley, W. N, 1968). The de novo pathway is initiated with the active form of ribose from ribose-5-phosphate to 5-phosphoribosyl-1-pyrophosphate (PRPP) and this synthesis discharges AMP. PRPP gives rise to the first nucleotide called inosine monophosphate (IMP) by an enzyme PRPP amidotransferase which serves as the rate-limiting step. Besides, IMP uses as a forerunner of AMP and GMP synthesis and the route of pathway is modulated by the higher level of particular nucleotide (Fox, I. H and Kelley, W. N, 1971). There are two main transferase enzymes involving in the purines salvage pathway. HPRT is responsible for catalyzing the hypoxanthine to inosine monophosphate (IMP) and guanine to guanosine monophosphate (GMP) and another one is adenosine phosphoribosyltransferase (APRT) which assembles adenine to AMP through transferring the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate (PRPP) (Keebaugh et al., 2007). The AMP, GMP, IMP are all catabolized to uric acid and particular mononucleotides is started with the transformation to the phosphate free nucleoside via cytosolic 5-nucleotidases. After that, the nitrogen is eliminated from adenosine to produce inosine with an enzyme, adenosine deaminase (ADA). The ribose is discarded from the nucleotides by purine nucleoside phosphorylase (PNP) and create hypoxanthine, xanthine and guanine (Rubin, C. S.et al, 1969). The nitrogen is then eliminated from guanine through guanine deaminase and xanthine is produced. Eventually, hypoxanthine and xanthine are converted to the final product of purine catabolism called uric acid by xanthine oxidase (Kelley, W. N, et al, 1970). It can be concluded that HGPRT deficiency leads to higher level of PRPP because of its rate limiting function and decreased level of GMP and IMP, resulting in increased de novo purine synthesis and degradation of purines to contribute to the higher level of uric acid called hyperuricemia and cause Lesch-Nyhan syndrome (Rosenbloom, F. M, et al, 1968). Thirdly, the biochemical defects can be determined by the purine metabolism of the Lesch-Nyhan syndrome and the metabolism can indicate the rate of uric acid synthesizing from 14C-labeled glycine (Sweetman, L. 1968). Also, the deficiency of HPRT contributes to the excessive purine synthesis and this enzyme acts as a regulating role in purine metabolism. The specific activity of the uric acid can be examined by the isolation and purification from urine. In the children with Lesch-Nyhan syndrome it is observed that accelerated specific activity in the uric acid obtain 20 times higher glycine concentration salvaged in uric acid than the control individuals (Nyhan, W. L.et al, 1968). Thus, it leads to the higher level of purine overproduction in patients. Besides, the rate of de novo synthesis of purine using fibroblasts grown in cell culture can be demonstrated (Seegmiller, J. E., et al, 1967). There is a significant relationship between asperity of disorder and recycle of hypoxanthine or guanine. The expressions of intracellular purines are normal within the fibroblasts with deficient HGPRT but purine depletion is apparent since the increased purine metabolites are discharged from cells. In addition, the normal purines were probable to cause a compensative increase in purine synthesis due to notable rising in purinosomes. Moreover, the purine de novo overproduction showing in this syndrome is an unsuccessful feedback regulation. The first step of the purine pathway is catalyzed by phosphoribosyl pyrophosphate amidotmnsfemse and is dependent to feedback inhibition by adenine and guanine. 2-ethylamino-l,3,4-thiadiazole was used for the examination and the observation showed that uricogenic agent significantly increases the rate of purine synthesis in normal conditions but in the patients the rates of purine synthesis increase more intensely by this agent (Nyhan, W. L.et al, 1968). Furthermore, the existence of xanthinuria in patients with inborn deficiency of xanthine oxidase expresses the abnormalities in the central nervous system. In the cerebrospinal fluid (Sweetman, L. 1968) the xanthine levels are equivalent to the controls and the hypoxanthine level in patients with the Lesch-Nyhan syndrome were greater than the controls by four times. Hence, Hypoxanthine and guanine recycling and the de novo pur ine synthesis are demonstrated to determine the biochemical abnormality of Lesch-Nyhan syndrome. In conclusion, by the discussion of the inheritance, molecular and biochemical defects that determining the clinical trait correlated with the Lesch-Nyhan syndrome, it is demonstrated that this X-linked recessive disorder is exclusive for males and is induced from the mutation of HGPRT gene which contributes to the overproduction of uric acid by purine salvage pathway and causes neurobehavioral problems of affected individuals (Rosenbloom, F. M.et al, 1968). For the future perspectives, although there is no treatment to cure this disorder, effective medications can be adopted to alleviate the symptoms such as managing the uric acid levels by allopurinol and reducing behavioral problems by taking diazepam or haloperidol appropriately (Genetics Home Reference, 2007). (Word count: 1639) References: Fox, I. H and Kelley, W. N. 1971. Ann. Intern. Med. 74:424-33  Genetics Home Reference, 2007. Lesch-Nyhan syndrome. Retrieved on 24/5/2007. Greene, M. L and Boyle, J. A, 1970. Science 167:887- 89 Hoefnagel, D, et al, 1965. Hereditary choreoathetosis, self-mutilation and hyperuricemia in young males. New Eng. J. Med. 273: 130-135, 1965. IFFA, 2016. Lesch-Nyhan Syndrome on emaze. [digital image] Retrieved from: https://www.emaze.com/@ACFTIZWL/Lesch-Nyhan-Syndrome Jinnah, H. A and Friedmann, T. 2001. Lesch-Nyhan disease and its variants.In: Scriver, C. R.; Beaudet, A. L.; Sly, W. S.; Valle, D. (eds.): The Metabolic Molecular Bases of Inherited Disease. Vol. II. (8th ed.) New York: McGraw-Hill (pub.) P. 2537. Kelley, W. N, 1968. Fed. Proc. 27: 1047-52 Keebaugh, A. C and Sullivan, R. T, 2007. NISC Comparative Sequencing Program, Thomas, J. W. Gene duplication and inactivation in the HPRT gene family. Genomics 89: 134-142. Kelley, W. N, et al, 1970. Biochim. Biophys. Acta 21 5 :512-16 Lesch, M and Nyhan, W. L, 1964. Am. J. Med. 36:561-70 Mumues, 2015. Mental retardation. [digital image] Retrieved from: https://www.slideshare.net/mumues/mental-retardation-44326087 Migeon, B. R, et al, 1968. X-linked hypoxanthine-guanine phosphoribosyl transferase deficiency: heterozygote has two clonal populations. Science 160: 425-427. Nyhan, W. L, 1967. Pediat. 67 :257-63 Nyhan, W. L, et al, 1968. Metabolism 17 :846-53 Nyhan, W. L, et al, 1970. Proc. Nat. Acad. Sci. USA 65:214-18 Page, T, et al, 1987. Syndrome of mild mental retardation, spastic gait, and skeletal malformations in a family with partial deficiency of hypoxanthine-guanine phosphoribosyltransferase. Pediatrics 79: 713-717 Rubin, C. S, et al, 1969. J. Lab. Cfin. Med. 74:732-41 Rosenbloom, F. M, et al, 1968. Bioi. Chern. 243 : 1 166-73 Seegmiller, J. E, et al, 1967. Science 155: 1 682-84 Sweetman, L. 1968. Fed. Proc. 27 : 1 055-59 Sweetman, L and Nyhan, W. L. 1972. Arch. Intern. Med. 130:214-20 Torres R J and Puig J G, 2007. Hypoxanthaine-guanine phosphoribosyltransferase (HPRT) deficiency: Lesch- Nyhan Syndrome. Orphanet J Rare Dis. 2, 1. [digital image] Retrieved from: https://en.wikipedia.org/wiki/Lesch%E2%80%93Nyhan_syndrome#/media/File:HPRT_metabolism.jpg Vogel, F, 1977. A probable sex difference in some mutation rates. (Editorial) Am. J. Hum. Genet. 29: 312-319.   Ã‚  

Wednesday, November 13, 2019

The Old Man And The Sea :: essays research papers

The book The Old Man and the Sea by Ernest Hemingway, is about an old man, Santiago, and his genuine fondness of the sea. Every day he travels out to sea to go fishing which is his occupation. For the past eighty-four days the old man has not caught a single fish. On the eighty-fifth day he sails out to sea as usual, and this is the day that changes Santiago's life forever. He hooks an unusually immense marlin, and they have an agonizing battle for several days. Hemingway often compares Santiago with the younger fisherman and describes various particular parts about the beautiful sea. This allows the reader to learn that Santiago especially loves the sea and is unlike the other fisherman. While Santiago is going out to sea on the first morning, Hemingway includes numerous details about the setting. Some of the details are to inform the reader that the old man really enjoys and values the ocean. One way which Hemingway shows this is that Santiago refers to the sea as "la mar," a kind and beautiful yet sometimes cruel feminine creature. Younger fishermen refer to the sea as "el mar," which is masculine. Changing this to be masculine means that they do not feel that the sea has any beauty or significance other than for money. Another way that the author tells that the old man appreciates the ocean is in one of his descriptions in the book. "Most people are heartless about turtles because a turtle's heart will beat for hours after it has been cut up and butchered. But the old man thought, I have such a heart too and my feet and hands are like theirs." Since Santiago has spent so many years of his life at sea he sees the beauty of the sea and the beauty of its creatures. This is also noted in another quotation from the book, "The iridescent bubbles were beautiful. But they were the falsest thing in the sea and the old man loved to see the big sea turtles eating them." Santiago finds pleasure about everything in the sea, even after going a disappointing eighty-four days without a fish. All of these are examples of how much the old man appreciates the sea. Other details Hemingway uses are to show Santiago's loneliness. He creates an image that the ocean is practically the old man's home.

Sunday, November 10, 2019

Kenaf

Kenaf composites experience a number of damage modes under dynamic compression loading. Therefore, in order to understand the overall behavior of the Kenaf composite, it is necessary to identify the different types of impact damage that occurred. Damage of composites such as cracking constituents usually occur and are not totally visible. To understand it, examination and analysis of specimens are needed. Microscope observation was used to observe the morphology of fractures of tested samples. This technique has been largely considered in various investigations of composites. The observed images of the fractured specimens under dynamic compressive test are shown in figure 9. On the top surface, it can be seen that the impact damage spreads throughout the specimen. These damage modes include degradation of the fiber/matrix bond strength and eventual debonding, matrix cracks, and fiber splitting, resulting in overall stiffness and strength degradation of the composite. This failure of the matrix material can originate from various loading conditions. In all cases, cracks initiate or propagate within the matrix or at the interface between fiber and matrix, if the respective loading condition of normal stresses or shear stresses exceeds the local strength of the matrix or interface, respectively. While bulk of the failure involves cracking of matrix, or interface debonding, fiber splitting may occur especially if fiber itself is weak in transverse direction, and the unidirectional composite is highly aligned in transverse direction. Referring to Fig. 7, longitudinal ply splitting or matrix fractures parallel to the fibre direction occurs and extends from the top and to the bottom surfaces. So, at the moment of impact, stress concentration is generated at the contact point where the matrix cracks and fiber bundles split. On the one hand, the stress wave propagates along the fiber direction, the fiber bundles act as the main load-bearing object, and fewer cracks can be seen along the longitudinal direction. Moreover, Figs. 9 shows a higher extent of fiber splitting and bending, which confirmed lower fiber-matrix adhesion, also indicates fibers were carrying higher load share than matrix (Ku et al. 2011).Based on the results of the experimental investigation, bonding at the fiber-matrix interface is identified as the dominant compressive failure mechanism in Kenaf composites which controlling the mechanical performance. Previous study have also shown that debonding of the fiber/matrix interface has caused substantial degradation in the transverse response of a composite, resulting in an early degradation in the stress-strain curve [33]. Besides, multiaxial tests conducted by Lissenden, et al. [34] on SiCTi tubular specimens revealed that fiber/matrix interfacial debonding plays an important role in the axial shear response. The mechanical properties of natural fibre reinforced composites highly depend on the interface adhesion property between the fibres and the polymer matrix as have been reported by many researchers [5–8]

Friday, November 8, 2019

buy custom Quality Education should be Made Affordable and Compulsory essay

buy custom Quality Education should be Made Affordable and Compulsory essay Prescriptive Argument: Good education in the USA is way too expensive for the majority middle class to afford. Majority of children from middle and low class income earning familys are left with no option but to attend the cheap or free public schools which offer low quality standard education. Good education should be made affordable and not just available but compulsory for all. Any child born has a right not just to education, but to quality education. According to Ashlock (1996), it appears that some familys still dont realize the importance of good education and therefore, quality basic education should not only be made affordable and available but also compulsory. Descriptive Argument: As described under the millennium goals, education is a basic requirement for any person in the world. Besides general education, statistics show that the quality of education an individual gets is highly influential to that persons future. Good education requires resources and facilities that are expensive to purchase and maintain. Therefore, good education tends to be expensive and unreachable to the common man (Ficksman, 2010). This has had an effect of creating a cycle of poor education among the majority in society. Only a few individuals manage to break through from the cycle and become wealthy. In order to break such cycle and provide equal opportunity for all kids, the government needs to facilitate for the availability and affordability of quality education (Johnson 2008). Given that some families among the middle class and poor may not understand the importance of good education, the government needs to make good education not only affordable and avail able, but also compulsory. This shall help in diversifying opportunities and reducing the wealthy and the middle class gap that exists today. Indeed, access to good or quality education is what governments need to consider if they are o sustainably solve other challenges in society. Buy custom Quality Education should be Made Affordable and Compulsory essay

Wednesday, November 6, 2019

Hemingways Code Hero essays

Hemingway's Code Hero essays Ernest Hemingway has created hundreds of novels and short stories that have made many significant contributions to literature. His work is well know around the world for its interesting composition by how he ties his personality and morals into his characters, which follow the beliefs, also know as "the code", that he lives by. Hemingway uses his code hero, who is named in most of his novels as Nick Adams to teach readers a creative and disciplined way of life. His code hero measures himself by how well he handles the sometimes vehement situations that life throws at him. He defined the code hero as "a man who lives correctly, following the ideals of honor, courage, and endurance in a world that is sometimes chaotic, often stressful, and always painful. Nick Adams is an individualist, always yearning to travel, while on a constant quest to conquer his fear of death, which would grant him his rights to becoming a man. These characteristics will be the topics discussed in this research paper. Nicks individuality is a paramount aspect in his life. He wants to remain a free spirit, not tied down by the complications of a normal, uneventful life. In the story The End of Something, Nick Adams Has a relationship with a woman named Marjorie. He realizes they are becoming closer as a couple. He interprets the relationship as a restriction on his individuality, that intern would destroy his ability to sate his desire for fun. He knew that if he married he would have to settle down, becoming compliant with a typical job that required a boring daily routine. With marriage comes family, something Nick was not quite ready for. Also, he surmised that when he married he would be marrying Marjories whole family, making him just another part of a large unit. Since he didnt want to lose his free will he had to end his relationship with Marjorie. The code heros individualism is also shown in Big Tw ...

Sunday, November 3, 2019

Coursework of Management & Org. Behaviour Case Study

Coursework of Management & Org. Behaviour - Case Study Example In fact employees would perceive this as the quality of work life which directs on final outcomes as employee performance, motivation, individual satisfaction and personal growth and development in the organizational environment. Business organizations are those legal entities that engage themselves in the production of a good or service with the intention of selling it for a profit and are much more focused on the long run survival in achieving organizational goals such as profitability, shareholder satisfaction, market share and share price growth, corporate governance, sustainability, market leadership and so on. Google being an internet search engine is focused on serving customers worldwide by managing its organizational functions in the light of its strategically advantageous position over the years by understanding of the main components of competitive advantage and how to sustain it and analysis of the behavioral challenges faced by the company in modern business environment. Google indeed adopted some far reaching management practices to achieve organizational goals. The most powerful motivator of the workforce was the requirement to become shareholder of the company in addition to being an employee. Google's all employees served as equity holders with employee ownership. Next the company encouraged team work in which 3 to 4 employees were teamed together so that time waste in coordinating work effort could be reduced and employees would be motivated by team spirit. In addition to these employee friendly work practices and motivators a number of others were also adopted. In fact at Google, work teams tended to be smugly satisfied with their own performance in the absence of standards of reference. Performance of work teams has to be measured against relative performances of others and this requires common standards to be set up on a priority basis.Broader level of employee participation, minimal hierarchy, in-house expertise and problem solving and job rotation practices were good measures but they were not backed by a system of performance-based metrics. However, with the ever increasing threat of competition in the market, management practices at Google were oriented towards creating a pleasant work environment with a set of well defined corporate goals. Despite Google's growth, its management is constantly considering and encouraging employee interaction and the exchanging ideas among all level of employees and across the departments.However effective management practices must be aligned with organizational outcomes such as internal value chain enhancement, productivity and motivation parameters. Google is being practicing this kind of alignment in its strategy and policy with focusing on rewarding system for individuals and teams. HRM is a functional strategy that needs a freer organizational environment to develop into a code-based framework or model of convergence. Google's management practices were inherently flawed though it made some convincing efforts to identify workplace discontent issues and their implications for organizational outcomes. Organizational outc

Friday, November 1, 2019

Essay - Materials that are used to build a bridge debate & more

- Materials that are used to build a bridge debate & more - Essay Example h can build for example: bridges, building and roads, to get well known with this major the person must take Bachelor Degree to start his career that the highest degree for Civil engineering is PhD, which takes many years to get this degree, the places where the civil engineering can work is in factories, government and companies, in factories the civil engineer can make maintenance for the petrol drilling area and facilities, for the government he can make the roads and bridges which is the same for the companies but the differences is the name of the work, many places gives sponsor to students to study civil engineering, the reason why I chose to study civil engineering because I have a huge interest in buildings also I like doing physical things instead of sitting in the office all day, in my country they are getting developed such as in roads, building and making bridges to make the traffic goes smoother and getting ready for 2022 world cup, and another reason that why I chose ci vil engineering is that I have many recommendations from my family as it is a wanted major these days and will have a good career in this major also talking to many civil engineers they told me it is really good job also working outside not sitting in the office all the time. Liverpool John Moores University offers 4 years studying with foundation in order to graduate Civil Engineering as same as Northumbria University also both of them doesn’t have any optional modules to study like learning new language or taking a subject that isn’t relevant to the course, both them offers sandwich year which is taking break one year between second year and third year which is working for a whole year to a corporate or to a company and then go back to university and continue studying, also in comparing between these two university both of them offers part-time study which is taking less subject than the full-time study and also they will take much longer time to graduate depending on their

Wednesday, October 30, 2019

To what extent are issues of gender important in processes of flight Essay

To what extent are issues of gender important in processes of flight and forced displacement - Essay Example These women become especially vulnerable to flight and forced displacement when civil unrest and wars are fought by their mother countries or by their ethnic communities. These issues of gender impact differently on the processes of flight and forced displacement; in some instances, it may bear a heavier or much more significant impact as compared to other issues. This paper shall assess the extent to which the issues of gender bear importance in processes of flight and displacement. It shall use particular cases in order to present a clear explanation of the issues set forth in this paper. The extent to which issues of gender are important in processes of flight and forced displacement may be considered based on several points which relate to the impact that displacement can bring to a person’s life. Women are especially vulnerable because many of them are often subjected to rape, involuntary servitude and violence (Buscher & McKenna, 2006). These are abuses which are often successfully perpetrated on women because they are physically weaker and may not be able to fend off the violent and forceful advances of strong and powerful men. Nevertheless, â€Å"displaced and refugee women and girls are often resilient survivors, courageous protectors and untiring caregivers† (Buscher & McKenna, 2006, p. 1). However, these women must first face dangers unique to their gender like rape, gender-based violence and even forced labor. They are also in danger during various stages of displacement from their flight to their displacement and on to their return (Buscher & McKenna, 2006). They, along with their children, face these risks and dangers, even as they face the daily challenge of trying to survive with hardly any food, clothing, or shelter. In the case of the Afghan women, children and girls, they faced and they are still facing most of the dangers as previously mentioned above. Gender

Monday, October 28, 2019

Documents of American History Essay Example for Free

Documents of American History Essay John Adams is an important figure in the history of this country at the most important time in its history: the time of its birth. He is a towering figure in American History and his accomplishments speak to protecting the rights of his fellow men, even if those men were British soldiers accused of shooting Americans as was the case with the Boston Massacre of 1770. John Adams served as minister to France in 1777 when at that time, the colonists badly needed French intervention if they ever hoped to win the American Revolution. Adams also had a contributing role in America’s Declaration of Independence as he was a vocal member of the Continental Congress. Adams also wrote the Massachusetts State Constitution, including its Bill of Rights. All of the above mentioned speak to the love of freedom and the protection of these rights to which Adams spoke so dearly. So then why during the 20th century, was Adams almost vilified compared to his friend and one time enemy Thomas Jefferson? It is peculiar how History seems to take sides over one issue of vilifies or glorifies one person above his real role in life.   Both Thomas Jefferson and Abraham Lincoln enjoyed such an honor during the latter half of the 19th century and into the 20th. Only recently, when it is almost certain, that Jefferson fathered children of a mixed breed, yet still owned 200 slaves at a time, when Adams spoke to the emancipation of slavery, does the playing field become more level. This is especially true with David McCullough’s book John Adams, which actually sparked a Congressional insight into the importance of John Adams and a rethinking by the American public, spoke about the legacy of a man who was vital to the survival of this new experiment called the American Republic. Adams is vilified to a certain degree for two actions: forcing his bitterness over the loss of the 1800 election, not to greet the incoming President as is the custom now, and the dreaded Alien and Sedition Acts of 1798 which horrified Thomas Jefferson and helped lead to the one time best friends, not to speak to speak to each other for another twelve years. Both John Adams and Thomas Jefferson will be forever linked together in American history. The 2nd and 3rd presidents of The United States and one time best friends, who later became political rivals and has the distinction of dying on the same day; the 50 anniversary of the signing of the Declaration of Independence, were giants in the quest for American Independence. John Adams, twice, served as a diplomat to France both during the American Revolution as well as in the years immediately following the war. â€Å"Both Jefferson and Adams were very important times since historians later hailed French involvement in the American Revolution as what helped turned the tide of the war in the favor of the colonists.† (McCullough, 2001 p. 322) And as the war was nearing its end, John Adams wrote his state’s Constitution as well as its Bill of Rights. This Constitution, more than any other of its time, expanded these rights, to a greater degree than had been seen previously. Adams was instrumental in procuring the freedom of African Americans, who in Jefferson’s Virginia, would continue to be slaves or live in slave like conditions well after the end of the Civil War and despite the passage of the 13th, 14th and 15th Amendments. But it would not be until the 20th century that such ironies were given their proper attention. â€Å"But it would be the passage of the 1798 Alien and Sedition Act that would puzzle and infuriate all those that had been a part of the construction of the Constitution’s Bill of Rights in 1791 and specifically, the 1st amendment which protected, among others, a person’s right of free speech.† (Burns, 1997) This meaning has been expanded over the years but then as well as now, its first usage was to protect one who criticized the government, from reprisal. The 1798 Alien and Sedition Acts seemed to come in stark contrast to this most sacred of rights within the American Constitution. It said: â€Å"That if any persons shall unlawfully combine or conspire together, with intent to oppose any measure or measures of the government of the United States, which are or shall be directed by proper authority, or to impede the operation of any law of the United States Shall be punished by a fine not exceeding $5,000 or a term in prison between five months to six years.† (Commanger, 1947 p. 177) This Act would later be repealed only to see the light of day again in 1918 during WWI. But such measures, horrified Thomas Jefferson and in response, wrote along with his friend James Madison, the Kentucky and Virginia Resolutions which were in direct response to the Sedition Acts and portrayed the further split between the Federalist and Democratic Parties, made even wider by the personal disunion caused by Adams and Jefferson. The Kentucky and Virginia Resolutions stated that: â€Å"no power over freedom of religion, freedom of speech, or freedom of the press being delegated by the   United States by the Constitution, nor prohibited by it to the states, all lawful powers respecting the same did of right remain, and were reserved to the States, or to the people.† (Commanger, 1947 p. 179) This meant that Jefferson, always distrusting of big government and in line with his belief in states’ rights, proclaimed that the federal government had no jurisdiction in enforcing the Alien and Sedition Acts as well as the fact that such restrictions on human freedom was in express contradiction to the Constitution and the ideals in which the American Revolution was fought in the first place. Everyone who had been locked up or fined under the Alien and Sedition Act was either set free or reimbursed by the federal government along with written apologies when Thomas Jefferson took over as President in March of 1801.The feud between Jefferson and Adams, made even larger by the ugliness of the 1800 Presidential election, lasted until 1812, when both were out of public office. Jefferson started a correspondence with Adams in what would become one of the most poignant and heart filled pieces of American literature. They both reminisced about their time together, hoping that this experiment in human democracy called the United States was actually going to work or not. Apologies were not given but rather regret that so much time has been lost to two people that were so important to the nation as well as to each other, were expressed in the correspondence. And what has to be one of the greatest coincidences in American history, two giants of American freedom who did not always practice what they preached; Adams’ enforcement of the Alien and Sedition Acts, and Jefferson personally owning more than 200 slaves for most of his lifetime, but still responsible for the expansion of human rights in America, died on the 50th anniversary of the signing of the Declaration of Independence. Each died while saying that the other still lives. They were both right in that respect.

Saturday, October 26, 2019

Response to Article about Cystic Fibrosis Essay -- Biology

Cystic Fibrosis - Summary of Article It has been known for quite some time that CFTR is a cAMP regulated chloride ion channel whose mutation is intimately linked to cystic fibrosis (CF). However, the abnormality in the chloride ion channels is not the only biochemical peculiarity associated with the disease. Of particular interest to researchers is the finding that sodium ion (Na+) absorption in the cells of CF patients is both elevated and positively related to the cAMP concentration, whereas, in normal cells, cAMP concentration is inversely related to the rate of Na+ absorption. The malfunction of the Na+ pump becomes immediately apparent, for the primary symptom of CF is a chronic bacterial infection of the lungs, due to the abnormally low viscosity of the fluid which bathes the cellular epithelium; by pumping ions into the airway, rather than into the cell, a thermodynamically unfavorable concentration gradient of sodium ions is is established, in which the airway is hypotonic and osmosis is kinetically favored. In the case of CF, the local chloride pump is inoperative, and the sodium pumps are incredibly overactive, importing Na+ from the airway, and taking water out of the fluid inside the lungs in the process. Therefore, is is inappropriate to place the sole responsibility for the low fluid viscosity directly upon the mutation of the CFTR protein. Studies have demonstrated that the elevated Na+ absorption is not due to an overexpression of the Na+ transport protein, ENaC, in the membrane, nor can cAMP sensitivity be linked to a genetically mutated ENaC. The possibility that the altered CFTR indirectly led to the Na+ channel phenomena by altering the functionality of normal ENaC formed the basis of a hypothesis which ... ...The use of amiloride as a form of treatment is significant because amiloride actually helps the body in correcting the chloride and sodium ion concentration, thereby rehydrating the cells and thinning the mucus. This process differs from current treatments which loosen the mucus or dilute it so the patients can rids their lungs of the infectious substance more easily. Works Cited 1.) Purves, WK, Orians GH, Heller HC. Life: the Science of Biology. Sunderland: Sinauer Associates, Inc.; 1995. Chapter 15, Genetic Disease and Modern Medicine; pages 334-352. 2.) "CF-FAQ Part 1." Ed. Ron Trueworthy. CF-WEB. Internet. 10 September 1996. 3.) S. H. Wright, interview by group members. Tucson, Arizona, 22 October 1996. 4.) M. J. Stutts, C. M. Canessa, J. C. Olsen, M. Hamrick, J. A. Cohn, B. C. Rossier, R. C. Boucher, Science, v. 269, 11 August 1995, pages 847-850.

Thursday, October 24, 2019

Comment on the development of the character of Pip Essay

We are acquainted with Pip from the outset of the novel, the opening lines telling of his unfortunate name and of the untimely deaths of his parents. To the reader, Pip appears to be a perceptive young boy- his visions about his parents were very lurid and imaginative, considering they were only taken from the font and style of his parent’s tombstones. Pip talks in a very matter of fact manner, i.e. he has no feelings of sadness or guilt when he talks about both his parents and his brothers. His encounter with the convict is a catalyst for change in Pips character, we can see that he changes from being quite confident and sure of himself, to being paranoid and afraid. When Pip hears the guns of the prison-ships, he begins to worry quite spontaneously, and links the fact that a convict has escaped with his encounter in the graveyard. This makes Pip even more fearful, seeing as now he has no doubt that the convict will carry out the necessary incisions to take out his heart and liver, unless of course Pip delivers the food. After the drop off has been made, Pip’s character takes another turn, this time into the realms of paranoia. Straight after Pip came back to his house in chapter four, Pip’s first words were ‘I fully expected to find a constable in the kitchen, waiting to take me up.’ All the way through the Christmas dinner when Pip’s relatives were present, Pip was constantly on the edge of his seat- ready to hide under the table every time Mrs. Gargery left the room, his fears about the missing food and drink riding high in his hyper-paranoid state. When Pumblechook informed Pip of his imminent visit to Miss Havisham’s, Pip is filled with questions to do with the purpose of his visit, and we see the deeply inquisitive side of Pip. His visit and time there bred mixed feelings within Pip: feelings of shame, ungratefulness, jealousy and a very prominent inadequacy within himself. He wishes he had Estella for himself, he wishes he had Miss Havisham’s fortune and he wishes he was someone else. He wishes he was someone uncommon, and someone well educated, gentlemanly and with fair hands. These wishes and strong feelings awakened his inadequacy and thus inadvertently his expectations. Estella sets an inner turmoil into motion within Pip. He feels strong feelings of love, jealousy, dislike for her (and himself) and an intuition which says leave her well alone, while his reckless love for her is in direct conflict with this. His love for her is a mystery to even himself, he analyses scrupulously his interactions with her, and the cold and heartless things she does to him, and he himself cannot explain the feelings he has towards her. Pip’s expectations change the way Pip thinks. He no longer looks upon himself as common and due to a few hints here and there from Miss Havisham, is convinced that she is his secret benefactor and that she has set him and Estella up for each other. This knowledge that Pip thinks he has leads to a change in Pip’s character, whereas before he was thinking of ways to improve himself so that Estella would look more kindly upon him, he now thinks that he just has to sit back, relax and wait. The truth was a shock to Pip, in his own words: ‘The abhorrence in which I held the man, the dread I had of him, the repugnance with which I shrank from him, could not have been exceeded if he had been some terrible beast.’ His foolishness with which he had treated Estella became apparent and inwardly Pip wished he had done more. He became both guilty and ashamed, and he came to almost resent his good fortunes, close to but not.